The Orpheum Theatre in St. Louis, Missouri opened on September 3, 1917. The Southern Real Estate and Financial Company hired G. Albert Lansberg to design the building. Lansberg designed many theaters for the San Francisco-based Orpheum Theatre Circuit. The 2,300-seat Beaux arts theater cost $500,000 ($9.6 million with inflation) to build. Unlike many other theaters, the Orpheum did not have a formal opening with special guests and speeches. Opening day was a straight vaudeville ticket with two strongmen, a contortionist, two comedians, and a singer.

Many famous vaudeville acts performed at the Orpheum over the years, including Sophie Tucker, Eddie Foy, Fannie Ward, and Lee Morse. Harry Houdini, the famous illusionist and escape artist, performed at the Orpheum for a week on three separate occasions: the first began on February 13, 1922; the second on January 14, 1923; and the last on December 22, 1923. When vaudeville declined in the late 1920s, the theater switched formats and became a playhouse. It opened on Christmas Day 1929 with a production of David Belasco’s The Bachelor Father.

Warner Bros took the Orpheum over in 1934 and changed formats again, this time to motion pictures. A new screen, projectors, and a W.W. Kimball 2 manual organ were installed in the theater. It reopened on September 15, 1934, with a showing of “British Agent” starring Kay Francis and Leslie Howard. Warner Bros operated the theater until 1941, when the theater closed. It reopened two years later, as the Loew’s Orpheum Theatre on January 28, 1943, with a war bond event and a screening of “The War Against Mrs. Hadley” starring Edward Arnold and Fay Bainter.

On February 28, 1960, Loew’s Theatres Inc. announced that they wanted to move their operations to the nearby American Theater (a playhouse) since they could not easily install a 70mm screen at the Orpheum because of its balconies. They could convert the American Theatre at a much lower cost. Both theaters were owned by Southern Real Estate and Financial Company, which were in favor of the switch. However, because of the ruling of the landmark antitrust case, United States v. Paramount Pictures, Inc., which said that movie studios could no longer own the theaters in which their films played; Loew’s needed the permission of the Department of Justice to sign a new lease; the Department of Justice signed in March 1960. After a $300,000 renovation, the Orpheum reopened as the American Theatre on October 10, 1960, with a performance of The Music Man.

Local entrepreneurs Steve and Michael Roberts purchased the theater for $1.5 million in 2003. It underwent a two-year renovation and upgrade before reopening on April 10, 2005, as the Roberts Orpheum Theater. The first musical act to perform at the reopened theater was the Backstreet Boys. In 2012, Steve and Michael Roberts went bankrupt and were forced to close the theater. Jubilee World Inc., a music-oriented Christian ministry, bought the theater in late 2016, intending to reopen it as a performing arts center. However, no reopening date has been announced.